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Image Search Results
Journal: Radiation Oncology (London, England)
Article Title: Oncogene addiction and radiation oncology: effect of radiotherapy with photons and carbon ions in ALK-EML4 translocated NSCLC
doi: 10.1186/s13014-017-0947-0
Figure Lengend Snippet: Selective antiproliferative effect of TAE684 in ALK-positive NSCLC. The kinase inhibition profile by TAE684 (IC 50 , mapped by TREE spot ) as well as its 2D and 3D molecular structures (adapted from PubChem) are shown ( a ). Cell proliferation was assessed by counting viable cells 72 post treatment with a cell-permeant DNA-binding fluorescent dye (CyQuant-Direct) ( b ). Alternatively, cell proliferation was monitored longitudinally by live microscopy and the confluence levels as well as representative photomicrographs are presented ( c and d ). TAE684 potently inhibited cell proliferation in ALK-positive H3122 NSCLC but was less or not effective in A549 and LLC cells, respectively. Bars represent mean ± SD. TK: tyrosine kinase; Ctrl: control
Article Snippet: The kinase inhibition spectrum (IC 50 ) of TAE684 was visualized (Fig. ) and mapped by
Techniques: Inhibition, Binding Assay, CyQUANT Assay, Microscopy, Control